The Substance

Nan
2h 21m
2024
7.134 /10 (5,727)

Have you ever dreamt of a better version of yourself?

Overview

A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Country : France, United Kingdom, United States of America
Languages : English
Released Date: 2024-09-07

Top Billed Cast

Demi Moore

Elisabeth

Margaret Qualley

Sue

Dennis Quaid

Harvey

Edward Hamilton-Clark

Fred

Gore Abrams

Oliver

Oscar Lesage

Troy

Christian Erickson

Man at Diner

Robin Greer

Male Nurse

Tom Morton

Doctor

Hugo Diego Garcia

Diego - Boyfriend

Daniel Knight

Casting Director

Jonathon Carley

Assistant Casting Director

Jiselle Henderkott

Girl Auditioning / New Year's Eve Show Dancer

Akil Wingate

TV Host

Vincent Colombe

Man in Suit #1 - Harvey's Office

Billy Bentley

Man in Suit #2

Similar Movies

poster
The Tailor of Panama
2001-02-11 6.02

The Tailor of Panama

A British spy is banished to Panama after having an affair with an ambassador's mistress. Once there he makes connection with a local tailor with a nefarious past and connections to all of the top pol ...
Genre :Horror, Science Fiction, Thriller
poster
Hagazussa
2018-05-17 5.678

Hagazussa

In the 15th century, a young goatherd living alone in a mountain hut feels a dark presence in the woods. ...
Genre :Horror, Science Fiction, Thriller
poster
Nemesis
2010-10-27 4.2

Nemesis

Claire and Robert spend most of their time in a house they own in the beautiful and remote countryside in Italy. Their life seems to be perfect. But when Claire's sister gets murdered in the very same ...
Genre :Horror, Science Fiction, Thriller
poster
Appetite
1998-08-12 2.786

Appetite

The guests of the Station Hotel have assembled to play a game of cards. The loser will sleep in room 207, a room rumored to be haunted. It hasn't been slept in for 20 years. As their lives tangle in ...
Genre :Horror, Science Fiction, Thriller
poster
Frankenstein General Hospital
1988-03-11 4.3

Frankenstein General Hospital

A mad doctor puts together a new body by using body parts he steals from a mortuary at the hospital where he works. ...
Genre :Horror, Science Fiction, Thriller
poster
Welcome II the Terrordome
1995-01-20 5.8

Welcome II the Terrordome

Spike and his sister Anjela live in the Terrordome, a huge ghetto that all the blacks have been forced to live in. Jodie, Spike's pregnant white girlfriend, ran away from an abusive white boyfriend wh ...
Genre :Horror, Science Fiction, Thriller
poster
Mystery Science Theater 3000: The Movie
1996-04-19 6.516

Mystery Science Theater 3000: The Movie

Dr. Clayton Forrester figures he can rule the world if he deadens his subjects' brains by making them endure terrible movies. Exploiting his access to nearby satellite-dwellers Mike Nelson and his rob ...
Genre :Horror, Science Fiction, Thriller
poster
Baise-moi
2000-06-28 4.814

Baise-moi

Nadine and Manu are two mad women, as tidy as can be, almost perfectionists. They have several things in common: extreme sex, drugs, beer and the trigger. They find the solution to their problems with ...
Genre :Horror, Science Fiction, Thriller
poster
Anamorphia
2020-04-02 9

Anamorphia

A short film from the mind of MAKE. ART. NOW. This short was self-filmed during the Los Angeles COVID-19 shutdown. When Josh, a YouTuber, unexpectedly receives a package, it starts him on a journey of ...
Genre :Horror, Science Fiction, Thriller
poster
Der Mann im Keller
2008-06-02 0

Der Mann im Keller

Genre :Horror, Science Fiction, Thriller
poster
The Adderall Diaries
2016-04-15 5.292

The Adderall Diaries

Writer and Adderall enthusiast Stephen Elliott reaches a low point when his estranged father resurfaces, claiming that Stephen has fabricated much of the dark childhood that that fuels his writing. Ad ...
Genre :Horror, Science Fiction, Thriller
poster
What Lies Beneath
2000-07-21 6.43

What Lies Beneath

Norman and Claire Spencer are a seemingly happily married couple who uncover a terrible secret… a secret so disturbing it threatens to destroy them. ...
Genre :Horror, Science Fiction, Thriller
poster
Anamorphia II
2021-02-05 9

Anamorphia II

The sequel to Anamorphia (2020), Josh (Joshua Yeo) awakens from the dream, only to follow the rabbit hole, to unexpected consequences. ...
Genre :Horror, Science Fiction, Thriller
poster
Natura
2023-01-25 0

Natura

An unsettling mystery about desperation and class divisions in the age of digital capitalism. ...
Genre :Horror, Science Fiction, Thriller
poster
Scream
1996-12-20 7.4

Scream

A year after the murder of her mother, a teenage girl is terrorized by a masked killer who targets her and her friends by using scary movies as part of a deadly game. ...
Genre :Horror, Science Fiction, Thriller
poster
The Bitch
1984-09-05 5.2

The Bitch

After serving time for sexual assault, a disgraced cop finds work as a private detective and becomes enmeshed in a bizarre web that includes a gangster and his former girlfriend…the same woman who sen ...
Genre :Horror, Science Fiction, Thriller
poster
L.A. Vice
1989-10-01 3.857

L.A. Vice

Detective Jon Louroy Chance investigates a string of murders in Los Angeles and uncovers a ruthless kidnapping scheme. ...
Genre :Horror, Science Fiction, Thriller
poster
Flash Gordon: The Greatest Adventure of All
1982-07-16 6

Flash Gordon: The Greatest Adventure of All

Flash Gordon, Dale Arden and Dr. Hans Zarkov travel to the planet Mongo to fight the evil emperor Ming the Merciless. ...
Genre :Horror, Science Fiction, Thriller
poster
Endtime
2014-06-09 5.8

Endtime

Eight friends throw a goodbye party to welcome the end of the world. ...
Genre :Horror, Science Fiction, Thriller
poster
A Scanner Darkly
2006-07-07 6.798

A Scanner Darkly

An undercover cop in a not-too-distant future becomes involved with a dangerous new drug and begins to lose his own identity as a result. ...
Genre :Horror, Science Fiction, Thriller

Check These Out

poster
Smile 2
2024-10-16 6.59

Smile 2

About to embark on a new world tour, global pop sensation Skye Riley begins experiencing increasingly terrifying and inexplicable events. Overwhelmed by the escalating horrors and the pressures of fam ...
Genre :Horror, Science Fiction, Thriller
poster
Alien: Romulus
2024-08-13 7.169

Alien: Romulus

While scavenging the deep ends of a derelict space station, a group of young space colonizers come face to face with the most terrifying life form in the universe. ...
Genre :Horror, Science Fiction, Thriller
poster
Anora
2024-10-14 7.06

Anora

A young sex worker from Brooklyn gets her chance at a Cinderella story when she meets and impulsively marries the son of an oligarch. Once the news reaches Russia, her fairytale is threatened as his p ...
Genre :Horror, Science Fiction, Thriller
poster
Deadpool & Wolverine
2024-07-24 7.557

Deadpool & Wolverine

A listless Wade Wilson toils away in civilian life with his days as the morally flexible mercenary, Deadpool, behind him. But when his homeworld faces an existential threat, Wade must reluctantly suit ...
Genre :Horror, Science Fiction, Thriller
poster
The Wild Robot
2024-09-12 8.311

The Wild Robot

After a shipwreck, an intelligent robot called Roz is stranded on an uninhabited island. To survive the harsh environment, Roz bonds with the island's animals and cares for an orphaned baby goose. ...
Genre :Horror, Science Fiction, Thriller
poster
Heretic
2024-10-31 6.974

Heretic

Two young missionaries are forced to prove their faith when they knock on the wrong door and are greeted by a diabolical Mr. Reed, becoming ensnared in his deadly game of cat-and-mouse. ...
Genre :Horror, Science Fiction, Thriller
poster
Nosferatu
2024-12-25 6.703

Nosferatu

A gothic tale of obsession between a haunted young woman and the terrifying vampire infatuated with her, causing untold horror in its wake. ...
Genre :Horror, Science Fiction, Thriller
poster
Strange Darling
2024-08-14 6.923

Strange Darling

Nothing is what it seems when a twisted one-night stand spirals into a serial killer’s vicious murder spree. ...
Genre :Horror, Science Fiction, Thriller
poster
Joker: Folie à Deux
2024-10-01 5.396

Joker: Folie à Deux

While struggling with his dual identity, Arthur Fleck not only stumbles upon true love, but also finds the music that's always been inside him. ...
Genre :Horror, Science Fiction, Thriller
poster
Longlegs
2024-07-10 6.533

Longlegs

FBI Agent Lee Harker is a gifted new recruit assigned to the unsolved case of an elusive serial killer. As the case takes complex turns, unearthing evidence of the occult, Harker discovers a personal ...
Genre :Horror, Science Fiction, Thriller
poster
Blink Twice
2024-08-21 6.677

Blink Twice

When tech billionaire Slater King meets cocktail waitress Frida at his fundraising gala, he invites her to join him and his friends on a dream vacation on his private island. But despite the epic sett ...
Genre :Horror, Science Fiction, Thriller
poster
Venom: The Last Dance
2024-10-22 6.664

Venom: The Last Dance

Eddie and Venom are on the run. Hunted by both of their worlds and with the net closing in, the duo are forced into a devastating decision that will bring the curtains down on Venom and Eddie's last d ...
Genre :Horror, Science Fiction, Thriller
poster
Megalopolis
2024-09-25 5.176

Megalopolis

In a futuristic New York known as New Rome, visionary architect Cesar Catilina dreams of building "Megalopolis," a utopian city that redefines society’s limits. Opposing him is the corrupt Mayor Frank ...
Genre :Horror, Science Fiction, Thriller
poster
Gladiator II
2024-11-13 6.632

Gladiator II

Years after witnessing the death of the revered hero Maximus at the hands of his uncle, Lucius is forced to enter the Colosseum after his home is conquered by the tyrannical Emperors who now lead Rome ...
Genre :Horror, Science Fiction, Thriller
poster
Beetlejuice Beetlejuice
2024-09-04 6.943

Beetlejuice Beetlejuice

After a family tragedy, three generations of the Deetz family return home to Winter River. Still haunted by Betelgeuse, Lydia's life is turned upside down when her teenage daughter, Astrid, accidental ...
Genre :Horror, Science Fiction, Thriller
poster
Wicked
2024-10-16 6.917

Wicked

In the land of Oz, ostracized and misunderstood green-skinned Elphaba is forced to share a room with the popular aristocrat Glinda at Shiz University, and the two's unlikely friendship is tested as th ...
Genre :Horror, Science Fiction, Thriller
poster
Apocalypse Z: The Beginning of the End
2024-10-04 6.72

Apocalypse Z: The Beginning of the End

When a kind of rabies that transforms people into aggressive creatures spreads across the planet, Manel isolates himself at home with his cat, relying on his wits to survive; but soon they must go out ...
Genre :Horror, Science Fiction, Thriller
poster
Transformers One
2024-09-11 7.993

Transformers One

The untold origin story of Optimus Prime and Megatron, better known as sworn enemies, but once were friends bonded like brothers who changed the fate of Cybertron forever. ...
Genre :Horror, Science Fiction, Thriller
poster
Wolfs
2024-09-20 6.537

Wolfs

Hired to cover up a high-profile crime, a fixer soon finds his night spiralling out of control when he's forced to work with an unexpected counterpart. ...
Genre :Horror, Science Fiction, Thriller
poster
Terrifier 3
2024-10-09 6.795

Terrifier 3

Five years after surviving Art the Clown's Halloween massacre, Sienna and Jonathan are still struggling to rebuild their shattered lives. As the holiday season approaches, they try to embrace the Chri ...
Genre :Horror, Science Fiction, Thriller